In a systematic review and meta-analysis, we found significant racial and ethnic disparities in NAFLD prevalence and severity in the United States, with the highest burden in Hispanics and lowest burden in Blacks. However, data are discordant on racial or ethnic differences in outcomes of patients with NAFLD.

Highlights d Deep seq reveals an accumulation of mutations in chronic liver disease tissues d PKD1, PPARGC1B, KMT2D, and ARID1A are recurrently mutated d In vivo CRISPR screens validate functional relevance of Pkd1, Kmt2d, and Arid1a d Mutations seen in liver tissues but not in cancer promote hepatocyte fitness

In a retrospective study of patients diagnosed with HCC, we found racial/ethnic differences in outcomes of HCC to be associated with differences in detection of tumors at early stages and receipt of curative treatment. These factors are intervention targets for improving patient outcomes and reducing disparities.

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