This study was made to evaluate the immune response to polio virus vaccine among PEM children by measuring the level of circulating Immunoglobulin G (IgG) antibodies against polio virus (IgG-PV) after immunization with the primary series of POV, and determining the coverage rate of universal childhood vaccine for polio virus. A cross-sectional laboratory study was conducted in Department of Medical Microbiology and Clinical Immunology, Faculty of Medicine and Health Sciences, and Al-Sabeen University Hospital, Sana'a University. A total of 279 PEM children were selected and investigated for universal childhood vaccination coverage rate for polio vaccine. Blood samples were collected from all, then tested for levels of IgG-PV by ELISA method. For assessment IgG-PV levels more than 10 units/ml were considered protected against polio virus infection. The coverage rate of polio virus vaccine for first year vaccine was 96.8%; and 91.1% of vaccinated PEM children responded to the vaccine with mean level of 46.2 U/ml. A statistically significant difference was observed with respect to sero-protective IgG-PV between males and females (85.7% and 94.1% respectively, p=0.002); and older children (>37 months) (97.7%).We conclude that a small proportion of malnourished vaccinated children with a normal immune status were not serologically immune to polio virus infection, and remain to be reconsidered for either revaccination or booster doses due to lack of or inadequate response. PEM group gave slightly reduced response to OPV hence there is need to give this group IPV (injectable polio vaccine) along with OPV and different micro-nutrition deficiencies like Zinc and iron.

Objective: To determine the prevalence of anemia and its associated risk factors among final-year medical students at Sana'a University, Yemen. Methods: This cross-sectional study was conducted among 269 final year students randomly selected from the medical faculties of Sana'a University in the period from January to April 2018. Data were collected using a structured questionnaire, while venous blood samples were collected by venipuncture into EDTA tubes. Hemoglobin (Hb) concentration was estimated using an automated hematology analyzer in the Laboratory Department of the University of Science and Technology in Sana’a city. Data were analyzed using appropriate statistical tests, and statistical significance was considered at P-values <0.05. Results: The mean Hb concentration of final-year medical students at Sana’a University was 15.1 ± 1.9 g/dL. The mean Hb concentration for male students was 16.3 ± 1.5 g/dL, while the mean Hb concentration for female students was 13.1 ± 1.5 g/dL. Anemia was prevalent among 12 (4.5%) out of 269 medical students and was significantly associated with the gender and smoking status of the students, where females (OR = 5.9, 95% CI: 1.8–27.4; P = 0.011) and smokers (OR = 6.3, 95% CI: 1.2–3.7; P = 0.002) were about six times more likely to be anemic compared to their counterparts. In contrast, there was no statistically significant association between anemia and age, family size, family income, presence of chronic disease(s), khat chewing, exercise, or history of blood transfusion. Conclusions: The prevalence of anemia among final-year medical students at Sana'a University is low compared to other studies elsewhere. The female gender and smoking are the risk factors significantly associated with anemia among medical students. Further large-scale studies among medical and non-medical students from different levels of study at public and private universities of the country are recommended.

Objective: To estimate the underlying primary diseases of chronic renal failure (CRF) among patients attending Al-Thawra General Hospital, Sana'a, and Yemen.Methods: This was a cross-sectional, hospital-based study of 566 patients diagnosed with chronic kidney diseases (CKD). It studied the cases attending Al-Thawra General Hospital over a three-year period from January 2013 to December 2015.Results: Out of 566 patients, 339 (59.9%) were males. The mean age of the patients at diagnosis of CKD was 39.51 years, most of whom (36.6%) were of the age group of 21-35 years. Hypertension was the most frequent cause (43.2%) of CRF, followed by different infectious diseases such as malaria, schistosomiasis and bacterial infections (19%) and obstructive nephropathy (17.9%). On the other hand, CRF of unknown etiology represented 15.2% of cases. Other causes of CRF diabetic nephropathy (9.7%), effect of antibiotics and analgesics (7.0%), ischemic heart disease (4.8%, polycystic kidney disease (3.5%) and congenital anomalies (3.4%). The least common causes were autoimmune diseases, bleeding, traumatic accidents and chronic diarrhea, being responsible for 2.2%, 1.8%, 0.9% and 0.4% of CRF cases, respectively. Conclusions:The majority of CKD cases in our study were males aged between 21 and 35 years old. In addition, most cases of CKD are due to hypertension, followed by infections and obstructive nephropathy. Application of future prevention and control measures are highly recommended to reduce the burden of CRF in Yemen for early detection and proper management of its underlying primary conditions/diseases.

Objective: To estimate the underlying primary diseases of chronic renal failure (CRF) among patients attending Al-Thawra General Hospital, Sana'a, and Yemen.Methods: This was a cross-sectional, hospital-based study of 566 patients diagnosed with chronic kidney diseases (CKD). It studied the cases attending Al-Thawra General Hospital over a three‐year period from January 2013 to December 2015.Results: Out of 566 patients, 339 (59.9%) were males. The mean age of the patients at diagnosis of CKD was 39.51 years, most of whom (36.6%) were of the age group of 21–35 years. Hypertension was the most frequent cause (43.2%) of CRF, followed by different infectious diseases such as malaria, schistosomiasis and bacterial infections (19%) and obstructive nephropathy (17.9%). On the other hand, CRF of unknown etiology represented 15.2% of cases. Other causes of CRF diabetic nephropathy (9.7%), effect of antibiotics and analgesics (7.0%), ischemic heart disease (4.8%, polycystic kidney disease (3.5%) and congenital anomalies (3.4%). The least common causes were autoimmune diseases, bleeding, traumatic accidents and chronic diarrhea, being responsible for 2.2%, 1.8%, 0.9% and 0.4% of CRF cases, respectively.Conclusions: The majority of CKD cases in our study were males aged between 21 and 35 years old. In addition, most cases of CKD are due to hypertension, followed by infections and obstructive nephropathy. Application of future prevention and control measures are highly recommended to reduce the burden of CRF in Yemen for early detection and proper management of its underlying primary conditions/diseases.

Objective: To determine the prevalence of anemia and its associated risk factors among final-year medical students at Sana'a University, Yemen. Methods: This cross-sectional study was conducted among 269 final year students randomly selected from the medical faculties of Sana'a University in the period from January to April 2018. Data were collected using a structured questionnaire, while venous blood samples were collected by venipuncture into EDTA tubes. Hemoglobin (Hb) concentration was estimated using an automated hematology analyzer in the Laboratory Department of the University of Science and Technology in Sana’a city. Data were analyzed using appropriate statistical tests, and statistical significance was considered at P-values <0.05. Results: The mean Hb concentration of final-year medical students at Sana’a University was 15.1 ± 1.9 g/dL. The mean Hb concentration for male students was 16.3 ± 1.5 g/dL, while the mean Hb concentration for female students was 13.1 ± 1.5 g/dL. Anemia was prevalent among 12 (4.5%) out of 269 medical students and was significantly associated with the gender and smoking status of the students, where females (OR = 5.9, 95% CI: 1.8–27.4; P = 0.011) and smokers (OR = 6.3, 95% CI: 1.2–3.7; P = 0.002) were about six times more likely to be anemic compared to their counterparts. In contrast, there was no statistically significant association between anemia and age, family size, family income, presence of chronic disease(s), khat chewing, exercise, or history of blood transfusion. Conclusions: The prevalence of anemia among final-year medical students at Sana'a University is low compared to other studies elsewhere. The female gender and smoking are the risk factors significantly associated with anemia among medical students. Further large-scale studies among medical and non-medical students from different levels of study at public and private universities of the country are recommended.