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Background: In recent years, MRI has increasingly become the modality of choice for imaging of musculoskeletal disorders. Diffusion weighted MR sequences provide microscopic information to supplement the macroscopic information provided by conventional sequences. It is a non invasive imaging technique which is suitable for probing the physical structure of a biologic tissue at a microscopic level and it exploits the random, translational motion of water protons in a biologic tissue, which reflects the tissue specific diffusion capacity and can be used for tissue characterization. Aim of Work:The aim of this study is to determine the value of Diffusion Weighted Imaging (DWI) in differentiation between different causes of vertebral collapse. Patients and Methods:This is a prospective study carried out in Radiofor patients diagnosed with vertebral body collapse. A total number of 35 patients (20 males and 15 females) with age range 18-74 (average 52).Conclusion: Diffusion weighted MRI can be used as a reliable tool in differentiation between different causes of vertebral body collapse. DWI could be applied as a cost effective substitute for the gadolinium enhanced scan especially in patients with contraindication for contrast administration.