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Egypt ABSTRACTA simple and sensitive saectrophotometric method is described for the assay of some tranauillixers and antidepressants, namely, chlorpromaxine, imipramine, amitriptyline and chlorprothexine. The method was based on the interaction of these drugs as n-electron donors with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as -acceptor to give a highly coloured radical anion which exhibits maximum absorption at 460 nm, The radical anion was proved by electron sain resonance measurements.The proposed method has been successfully anplied for the determination of the examined drugs in tablets. The 1391 Copyight 0 1985 by Marcel Dekker, Inc.

A colorimetric method for determining thymol and eugenol in volatile oils is presented. Thymol and eugenol are reacted with sodium cobaltinitrite in aqueous acetic acid. The yellow color produced is measured at 330 and 370 nm in chloroform, and at 396 and 450 nm in sodium hydroxide solution for thymol and eugenol, respectively. The method is applied to the assay of thyme oil (thymol type) and clove oil. The results obtained are reasonably reproducible with a coefficient of variation less than 2%.

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