In general, stress affects the efficiency of workers’ performance. With the coronavirus disease 2019 pandemic outbreak, sign language interpreters experience increased stress due to various factors. This study aims to determine the stressors faced by sign language interpreters during the pandemic. To achieve this goal, we prepared a questionnaire consisting of 15 paragraphs covering psychological, health, cognitive, linguistic and environmental aspects. Then, we surveyed 57 sign language interpreters in the Arab region. In the analysis, we calculated the average performance levels in addition to the differences between participants’ average scores. We also divided the stress levels into three categories: simple, moderate and severe. Results indicated that the stress was medium on average and no statistically significant differences in the performance average in accordance with the study variables (gender, experience and workplace).