No abstract

Angiography after arterial percutaneous closure using Prostar XL device during TAVI allows detection and endovascular treatment of vascular complications and is associated with low rate of conversion to open surgery.

and control limbs in the not-trained group and the trained group for the analysis of the mitochondrial function: mitochondrial respiration, calcic retention capacity, markers of biogenesis and antioxidant defenses. Results: For the not-trained mice, mitochondrial respiration was impaired in the ischemic limbs compared to the control limbs (Vmax¼7.11 ± 1.14 vs. 9.86 ± 0.86 mmol 02/min/g dw, p<0.001), just as the calcic retention capacity (CRC¼7.01 ± 0.97 vs. 11.96 ± 0.92 microM/mg dw, p<0.001). For the trained mice, mitochondrial respiration and the calcic retention capacity were restored in the ischemic limbs compared to the control limbs (Vmax ¼ 9.75 ± 1.00 vs. 9.82 ± 0.68 mmol 02/min/g dw; CRC¼11.36 ± 1.33 vs. 12.01 ± 1.24 microM/mg dw). The markers of biogenesis (PGC1alpha, PGC1beta, NRF1) and antioxidant defenses (SOD1, SOD2, and catalase) were higher in the group of trained mice compared to the not-trained mice. Conclusion: The exercise of moderate intensity has a beneficial effect on the skeletal muscle in chronic ischemia, by restoring the mitochondrial function, via the activation of mitochondrial biogenesis and antioxidant defenses. This opens the door towards the proposal for new types of rehabilitation programs for the patients with chronic ischemia, in particular for the patients not being able to benefit from a procedure of revascularization.