Thirty-six V-line male rabbits ten months age, average weight 3.5 kg were used. They were allocated randomly into six equal groups. First and second were served as a negative (NC) and positive (PC) control. Third group was injected by double dose (1mg/kg body weight) of ivermectin (IV) via subcutaneous injection, fourth, fifth and sixth groups were treated with 5% garlic oil (GO), 5% cinnamon oil (CO) and 5% garlic oil + 5% cinnamon oil mixture (MO), respectively. Rabbits were treated GO, CO and MO received daily topically treatment for 7 successive days. Groups PC and IV were treated with paraffin oil and ivermectin. Blood samples were collected at 1, 7 and 14 days of treatment to biochemical analysis. Semen characteristics and reaction time (libido) were recorded.Results showed that there were a significant (P≤0.05) decreased in total protein, albumin, globulin, testosterone, semen characteristics, TAC in rabbits infested groups compared with NC group. But there were a significant (P≤0.05) increase in ALT, AST, creatinine, urea and uric acid, cortisol, T 3 and T 4 , MAD in the rabbits infested groups compared with NC group. Rabbits treated with ivermectin recorded a significant (P≤0.05) decrease at 1 and 7 days in serum total protein, albumin compared with other groups, while, globulin decreased gradually from day 1, 7 and 14 comparable with other groups. Serum total protein, albumin, ALT, AST, creatinine, urea and uric acid were increased toward to NC group at 7 th and 14 th days of therapeutic.Garlic and cinnamon oils caused a decrease in ALT, AST, creatinine, urea and uric acid with time compared with PC and IV groups. While, injected ivermectin for infested rabbits led to significant (P≤0.