Aim: To assess and compare the cyclic fatigue resistance of EdgeFile X7, EdgeOne, WaveOne Gold and WaveOne rotary files using artificial canals with different angles and radii of curvature. Materials and methods:One hundred and sixty NiTi files from four different systems (N= 40 each) were used; Group 1: WaveOne, Group 2: WaveOne Gold, Group 3: EdgeOne and Group 4: EdgeFile X7. The files were tested for cyclic fatigue resistance using a custom made static model with various angles and radii of curvature (angle 60° radius 2.5mm and radius 5mm and angle 90° radius 2.5mm and radius 5mm). The files were operated according to the manufacturers' instructions inside the artificial canals till fracture. A digital stopwatch was used to record the time till fracture (TTF) in seconds and the length of the fractured segment (FL) was recorded. Results:The highest TTF values were found in the WaveOne Gold group followed by the EdgeOne group then the WaveOne group while the least was in the EdgeFile X7. There was no statistically significant difference between WaveOne Gold and EdgeOne at all angles and radii of curvature. There was a statistically significant difference between both the WaveOne Gold, EdgeOne and the EdgeFile X7. Angle 90° with 2.5mm radius showed the lowest cyclic fatigue resistance. WaveOne Gold and EdgeFile X7 showed lower FL compared to WaveOne. Conclusion:WaveOne Gold and EdgeOne showed superior comparable cyclic fatigue resistance which was higher than that of WaveOne while EdgeFile X7 showed the least cyclic fatigue resistance.