Background: Tomatoes are now one of the most popular nutrient-dense vegetables in terms of acreage, production, yield, commercial use, and consumption that add to the Bangladesh economy and ultimately reduce poverty. With this view, a lab investigation was carried out to analyze the effects of tomato (Sofol and Roma VF) verities on different post-harvest managements to extend shelf life as well as reduce post-harvest losses.Results: This study confirmed that the fruit quality attributes (color, firmness, weight loss, chilling injury, total soluble solids, pH, disease incidence, disease severity, and dry matter content) were increased whereas moisture content, vitamin C, and titratable acidity decreased with the increases in storage duration. The high quality attributes such as color, firmness, weight loss, chilling injury, total soluble solids, pH, disease incidence, disease severity, and dry matter content increased, whereas moisture content, vitamin C and titratable acidity decrease of tomato were observed in Roma VF while Sofol variety had high weight loss, moisture content, titratable acidity, and vitamin C. Moreover, the highest shelf life (17 days) was recorded in Sofol than Roma VF (15 days). On the 16th day of storage, maximum disease severity (41%) and disease incidence (71%) were observed at an earthen cooling pot, whereas a significant reduction in disease severity (1%) and disease incidence (8%) were recorded in tomatoes stored at 10 o C temperature. Weight loss was the lowest (4%) in Sofol when kept at unperforated low-density polyethylene (LDPL) plastic bag as compared to Roma VF treatment (11%). Considering the physiological process, held at the low temperature (10°C and 15°C) and increased shelf life as well as reduced the diseases of tomatoes. Conclusions: The investigator concluded that the findings of this study will be helpful with specific regard to long and medium-term storage, quality control, transportation, and advertising, and will also be beneficial to tomato growers of Bangladesh.