Lately, vaccination has been a widespread action to fight the pandemic, requiring the vaccines to be sent out to various places at various distances while staying at optimal quality, usually using cooler boxes. However, today's cooler boxes use ice instead of having a continuous refrigeration system. Thus, this paper presents a vaccine refrigeration box design and fabrication that uses a modified thermoelectric system as the refrigeration system, a conventional and solar charging system as its charging system, and a Bluetooth temperature sensor. From the result of the experiment, the box maintained full functionality for 210 minutes after being charged using a solar charging system. In terms of fully charging the power source, the conventional charging system takes 4 hours and 8 hours using the solar charging system.