Novel peptidomimetics containing dithiocarbamate groups were synthesized via the Ugi reaction. Also, dithiocarbamates of natural amino acids were prepared and were used successfully in Ugi reactions to prepare novel peptidomimetics bearing amino acid and dithiocarbamate groups in a single structure. In addition the prepared dithiocarbamates based on amino acids are converted to the corresponding amides.
Different benzofuran derivatives
are synthesized via a catalyst-free
reaction between nitroepoxides and salicylaldehydes. In the employed
methodology, K2CO3 and DMF have been used at
110 °C, and the reactions were completed after 12 h in 33–84%
yields. The highest yields were obtained using 3-nitrosalicylaldehyde.
Finally, a plausible mechanism was proposed for the reaction, and
some evidence was provided for this mechanism such as the detection
of released acetate anion (using FTIR) and isolation and structure
determination of the critical intermediate.
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