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Due to its biodegradable and biocompatible nature, poly(lactic acid) (PLA) has found widespread use in biomedical applications. Controlled drug delivery using PLA-based nanoparticles (PLA-NPs) is an important tool for tuning the bioavailability of therapeutics. Traditional methods to prepare PLA-NPs require a multistep process that is time-consuming and produces significant aqueous and organic waste streams. This work reports a one-pot mechanochemical synthesis of lactide to PLA-NPs. In this report, we developed and trained an artificial neural network algorithm to optimize PLA and PLA-NP preparation. Our results demonstrate a robust and optimized one-pot method for preparing precisely defined nanoparticles that generates minimal waste.

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