PCOS is an endocrine condition caused mostly by infertility and menstrual abnormalities. The pathophysiology of PCOS is related to the lack of hormone, reproductive and metabolic regulation which were stimulated by a variety of factors, such as insulin resistance. PCOS treatment strategies are always oral contraceptive pill (OCP) combination oral contraceptive pill, which can cause metabolism and cardiovascular side effect and is difficult to comply with consistently. Several studies stated that the combination between Myo-inositol and D-chiro-inositol (MI-DI) as therapeutics alternative to improve PCOS condition in reproductive-age women. This study investigates combination of MI-DI on PCOS in reproductive-age women. A literature review was used to conduct this investigation through PubMed, ScienceDirect, and Google Scholar databases. 1382 publications were identified in the search results, and 6 studies were relevant and matched the requirements for this investigation. MI-DI co-supplementation is effective to ameliorate metabolic and clinical abnormalities of PCOS patients.