Neurological manifestations are reported as a consequence of primary Sjӧgren syndrome (PSS). Any part of the brain and peripheral nervous system can be involved in PSS. However, cerebellar degeneration and atrophy associated with PSS have been rarely reported. Our report describes a 22-year-old woman who presented with cerebellar ataxia, arthritis and arthralgia. Evaluation of her symptoms, autoantibodies and salivary gland pathology was in favour of the diagnosis of Sjögren syndrome. Also, her brain MRI revealed cerebellar degeneration. There are only four patients reported to be affected by cerebellar atrophy associated with PSS. Administration of high doses of methylprednisolone and cyclophosphamide leads to substantial improvement in the cerebellar symptoms of this case. In addition, after 2 months of follow-up, the patient's ataxia recovered significantly. It could be concluded that in addition to neurological degenerative disorders, in some cases cerebellar atrophy could also be associated with autoimmune conditions such as PSS.

We present an 18-year-old male suffering from myalgia, cough, and anorexia with symptoms of jaundice and lymphadenopathy. He was infected with the Epstein-Barr virus which leads to acute lymphoblastic leukemia in this patient.

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Background & Objectives: Multiple Sclerosis (MS) is a potentially devastating disease in the central nervous system with an unknown etiology. Many epidemiologic and genetic studies are revealed that both genetic and environment can influence the susceptibility of MS. When microRNAs are introduced to molecular genetic world, they could establish their position in genetic studies. MiRNAs are small (19-24 nucleotides) noncoding RNAs. Here, we are trying to introduce the role of miRNAs in MS and their potentials to serve as biomarkers. Material & Methods: In this study we reviewed some different articles in a 10-years period about the role of miRNAs in MS. Then we selected the specific keywords and the most recent data were collected in this field. Results: The results show that many studies are performed on the role of miRNAs in various aspects of miRNAs in MS. In addition, miRNAs can be involved in the pathogenesis of MS, as well as they have some new therapeutic potential for MS through the gene expression regulation. Conclusion: Our results suggest that beside the role of miRNAs in MS pathogenesis, they have some therapeutic potential for MS. As well as, they can serve as biomarkers to evaluate disease progression and therapeutic efforts.