Objective. Vitamin C may be a beneficial adjunct for decreasing sore throat following tracheal intubation. Therefore, the aim of this study was to evaluate the effect of vitamin C infusion on post-intubation sore throat reduction. Methods. This double-blind randomized study was conducted on 70 patients undergoing elective laparoscopic surgery in Shahid Sadoughi Hospital. The patients were allocated into two groups (experimental and control). All patients received 2 mg midazolam and 100 microgram fentanyl citrate premedication. Thirty minutes after induction of anesthesia, 5 mg morphine was given to all patients. In the next step, the experimental group received vitamin C (2 g) mixed with normal saline for the total injection volume of 500 mL during 30 min and those in control group received normal saline without vitamin C.