Background: Despite the emergence and development of evidence-based practice (EBP) in recent years, its adoption continues to be limited. This study used Rogers’s diffusion of innovation theory to identify the factors that advance EBP adoption, determine the process by which such adoption occurs, and develop an EBP adoption model.Methods: This descriptive correlational study with model testing design conducted in 2015.Data were collected from 482 individuals (322 nurses and 160 nursing students) applying a demographic information questionnaire, a standard scale for the perception EBP attributes, an EBP scale, and an individual innovation inventory. The relationships between variables we reexamined by path analysis.Results: The results showed that EBP adoption had a significant positive relationship with individual innovation (r = 0.578, P < 0.001), knowledge (r = 0.657, P < 0.001), attitude (r = 0.623,P < 0.001), and age (r = 0.357, P < 0.001). The findings of path analysis indicated that the goodness of fit indices such as goodness of fit index (GFI) = 0.999, comparative fit index (CFI)= 0.999, root mean square error of approximation (RMSEA) = 0.036 were in the ideal ranges.Knowledge (total effect=0.309, P < 0.001), attitude (total effect = 0.372, P = 0.002), and work experience (total effect=0.321, P = 0.003) had the highest coefficient in the model.Conclusion: The results suggested that EBP adoption was influenced by various factors, such as individual innovation, attitude, knowledge, and the perception of EBP attributes. Among these factors, attitude had the greatest effect on EBP adoption. The findings can serve as a guide for the identification of factors that effectively influence EBP adoption. They can also be used as bases for the design of training programs intended to enhance the adoption of EBP.

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Background Oxidative stress is strongly associated with development of diabetes mellitus. F. vulgaris, contains antioxidant ingredients. This study was designed in order to evaluate the effect of F. vulgaris on the damaged liver in diabetic rats. Methods In this study, hydroalcoholic extract of F. vulgaris was prepared. Sixty four male rats were divided into 8 groups (n = 8), including saline (normal control), streptozotocin (STZ) (diabetic control) (60 mg/kg), F. vulgaris (50, 100, 150 mg/kg), and STZ plus F. vulgaris (50, 100, 150 mg/kg) were administered through oral gavage on treated group once a day for 28 consecutive days. Serum nitrite oxide (NO) level, Ferric reducing/antioxidant power (FRAP), Malondialdehyde (MDA), liver weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), diameter of hepatocytes and central hepatic vein have been examined. Statistical analysis was performed using one-way analysis of variance and the post hoc test. Result The outcomes showed that administrating streptozotocin enhanced liver MDA, nitrite oxide, the mean diameter of central hepatic vein and hepatocyte, liver enzymes significantly and reduced liver weight compared to saline group (P < 0.05). Though, administrating F. vulgaris and F. vulgaris plus STZ enhanced liver weight and tissue FRAP level significantly and reduced liver enzymes, NO levels, liver MDA, the mean diameter of hepatocyte and central hepatic vein in entire doses were equal to STZ group (P < 0.05). Conclusion It seems that, were equal F. vulgaris might recover liver injuries in diabetic rats.