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This paper presents an Optimum pre-filter for leA based mulit-input multi-output OFDM System. In our former work, we presented a pre-filter solution for multiuser reconstruction in leA based MIMO-OFDM systems [1], [2].Here, based on the structure of the system and former pre filter solution, an optimization problem has been designed to give us the optimum pre-filter. The designed problem is based on minimization of the estimation error of ambiguities inherent to leA in reconstruction of the data after separation. The optimization problem is mathematically solved and a set of optimized coefficients are obtained. Among the obtained set as optimum coefficients, optimum coefficients are acquired in a way not only minimize the estimation error of multiuser data reconstruction, but also lead the least error probability in detection of demodulated symbols.