This paper presents an empirical investigation to study the effect of human resources management on employee performance in one of Iranian social security organizations. The proposed study designs a questionnaire for human resources management with 23 questions consists of five components including Beneficiary groups, Long-term achievements, Situational factors, Human resources achievements and human resources achievement for measuring human resources management figures. In addition, the study uses another questionnaire consists of 37 questions for measuring organizational performance. Cronbach alpha for human resources management and organizational performance are calculated as 0.885 and 0.873, respectively. Using Pearson correlation ratio as well as stepwise regression technique, the study detects a positive and meaningful relationship between human resources management and organizational performance.