Experimental values of density and speed of sound for binary liquid mixtures of 2,5-dimethylfuran (2,5-DMF) with furfuryl alcohol (FA), methyl isobutyl ketone (MIBK), 1-butanol and 2-butanol and over the entire composition range of 2,5-DMF and at the temperature range of 293.15–323.15 K at 10 K intervals and at pressure p = 0.1 MPa were reported. Experimental data were used to assess the thermodynamics properties of studied mixtures. These properties were used to interpret the molecular interactions among component of liquids. The values of excess/deviation functions have been fitted to Redlich−Kister type polynomial equation. From the obtained results, a discussion was carried out in terms of nature of intermolecular interactions and structure factors in the binary mixtures.