Dengue is not only confined to its classical presentation of high-grade fever, body ache, shock, plasma leakage and thrombocytopenia. Itinvolves multiple organ like brain, heart, liver, abdomen, kidney, lungs, thyroid and causing concerning morbidity and mortality. In this review article we have tried to focus on the different variety of presentation which is now called Expanded Dengue Syndrome. This review article will be helpful to physician to combat Dengue virus where it is endemic. Bangladesh J Medicine 2022; 33: 5-9

Myelofibrosis (MF) is a rare disorder that is classified as one of the myeloproliferative disorders. It is a BCR-ABL1- negative myeloproliferative neoplasm characterized by abnormal proliferation of hemopoietic stem cells within the bone marrow, which leads to overproduction of fibrous tissue. Our patient a young girl of 17 year old presented with lump in left upper abdomen, shortness of breath & generalized swelling. The diagnosis was made based on severe anaemia, pancytopenia in peripheral blood film. Bone marrow trephine biopsy from the tibia revealed myelofibrosis. Splenectomy was done in an attempt to reduce the total volume of malignant cells and improve the features of hypersplenism. Myelofibrosis with hypersplenism in a 17- year- old girl is reported rarely. However, when it does, it usually runs rapid and fatal course. J Bangladesh Coll Phys Surg 2023; 41: 239-243

Most of the hospitalized patients are anaemic to some degree in our country and sometimes need blood transfusion. Complications of blood transfusion are rare but can be life-threatening. Since 2005, it has been a legal requirement that all serious adverse reactions attributable to the safety or quality of blood transfusion are reported. Most reported complications are because of transfusion of mismatched blood products and are avoidable with proper vigilance. A 45 year old female who underwent salpingo-oophorectomy with total abdominal hysterectomy for torsion of ovarian cyst and was transfused one unit of blood peroperatively. Blood grouping was accidentally incorrect and cross matching was not done. This mismatched blood transfusion resulted in acute renal failure. Patient was referred from the private hospital to Dhaka Medical College Hospital, Dhaka and was managed by forced alkaline diuresis and later, haemodialysis. Key words: Mismatched blood transfusion; haemolytic transfusion reactionDOI: 10.3329/jdmc.v19i2.7089J Dhaka Med Coll. 2010; 19(2) : 154-157

Background: COVID-19 vaccines have a high rate of success in averting hospitalization and mortality. However, COVID-19 infection is still being detected among immunized patients, although with blunted severity. This study aimed to compare the severity and outcome of COVID-19 among immunized versus non-immunized individuals. Methods: This cross-sectional study was conducted over 179 COVID-19 patients in Popular Medical College Hospital, Dhaka. All the methods in the present study were carried out following the ethical guidelines of the 1975 Declaration of Helsinki. Data were collected from both hospital record and direct interview. Data were recorded in separated case record form and analyzed by STATA version 14. Results: Mean age of the study patients was 55.42±14.20 (SD) years wherein maximum were male (61.5%). Fever (88.8%), cough (81.6%), dyspnea (47.5%) and sore throat (30.2%) were most common symptoms. Maximum patients werehypertensive (60.9%) and diabetic (58.7%). About 35.8% of patients had mild severity, while 27.9% had moderate, 23.4% had severe, and 12.8% had critical stage. Maximum patients (n=122, 68.2%) were nonvaccinated and rest (n=57, 31.8%) had received 1st dose of vaccine. Vaccinated patients had significantly higher frequency of having mild COVID-19 (57.9% vs 31.1%, p<0.001) and getting discharge with full recovery (94.7% vs 76.2%, p=0.003) compared to non-vaccinated patients. Moreover, non-vaccinated patients were more prone to develop critical clinical syndrome (10.6% vs 1.8%, p=0.039) and had died or referred to higher center (11.4% vs 1.8%, p=0.029) than vaccinated individuals. Conclusion: COVID-19 vaccination was significantly associated with mild severity and lower rate of adverse outcome. Bangladesh J Medicine 2022; 33: 293-299

Brucellosis is a Zoonotic disease which is not so common health problem in Bangladesh. For its variable presentation it creates diagnostic challenge for the clinicians. Although Brucellosis is a treatable and curable condition sometimes delay in diagnosis and lack of insight for the disease creates high morbidity. In this case report we have presented a case of brucellosis presented with prolong fever, joint pain with complications which created dilemma in diagnosis in a tertiary care private hospital of Dhaka. The purpose of presenting this case report is to create concern among the clinicians regarding the variablepresentation of Brucellosis& emphasizing to clinical judgment over investigations, especially in limited resources. Bangladesh J Medicine July 2022; 33(1) : 89-93