Regenerative medicine offers the potential to repair or substitute defective tissues by constructing active tissues to address the scarcity and demands for transplantation. The method of forming 3D constructs made up of biomaterials, cells, and biomolecules is called bioprinting. Bioprinting of stem cells provides the ability to reliably recreate tissues, organs, and microenvironments to be used in regenerative medicine. 3D bioprinting is a technique that uses several biomaterials and cells to tailor a structure with clinically relevant geometries and sizes. This technique's promise is demonstrated by 3D bioprinted tissues, including skin, bone, cartilage, and cardiovascular, corneal, hepatic, and adipose tissues. Several bioprinting methods have been combined with stem cells to effectively produce tissue models, including adult stem cells, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and differentiation techniques. In this review, technological challenges of printed stem cells using prevalent naturally derived bioinks (e.g., carbohydrate polymers and protein-based polymers, peptides, and decellularized extracellular matrix), recent advancements, leading companies, and clinical trials in the field of 3D bioprinting are delineated.

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Frequency dependent slug and stratified flow are generated on centrifugal microfluidics using only the centrifugal force.

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According to the fact that, in comparison with the other spirometers, a flow-based spirometer benefits from a wide range of advantages such as being easy to use and calibrate, in this study, we make an attempt to design the optimum turbine just by changing the geometry of blades in order to increase the efficiency of a flow-based spirometer. In fact, the aim of the study is to design and simulate different types of blades in order to increase the mixing of breathing air and decrease resistance to breathing. To reach this aim, blades with different shear angles have been investigated and the most appropriate one has been reported.