Background: Smartphone applications play a pivotal role in management, providing care and preventing infectious diseases. It also has the potential impact on supportive and self-care. This study aimed to identify the requirements for a smartphones self-care system to prevent corona-virus (COVID-19). Materials & Methods:This was a descriptive study performed in two main stages in 2020. At the first stage, to recognize the requirements for a smartphones self-care system, similar articles were searched and identified. In the second stage, the identified requirements were validated through a researcher-made questionnaire. The sample size of the study consisted of infectious diseases specialists of Urmia University of Medical Sciences. The collected data was analyzed using descriptive statistics (mean and frequency).Results: Requirements of the self-care system were identified in four areas: "demographic data, clinical requirements, selfcare strategies, and technical characteristics". Also, according to the research community, 5 data elements for demographic data, 11 data elements for clinical requirements, 5 data elements for self-care strategies, and 11 data elements for technical characteristics were selected. Conclusion:Applying the requirements and suggested strategies in the present study can improve self-care skills to prevent corona-virus, symptoms management, motivate and reduce stress, increase personal hygiene and communication with health care providers.

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