Antagonistic medication response (ADR) can be characterized as any toxic change which is suspected to be because of a medication, happens at dosages ordinarily utilized in man, requires treatment or decline in portion or shows alert later on the utilization of similar medication. Escitalopram is a medication which goes under the classification of particular serotonin reuptake inhibitors (SSRIs) (antidepressants). It is the S-enantiomer of the racemic subsidiary of citalopram, which specifically restrains the reuptake of serotonin with practically no impact on norepinephrine or dopamine reuptake. Practically all the antidepressants and antipsychotics have been connected to QT prolongation. In a patient with previously diagnosed congenital QTS, we present a drug-induced QT extension owing to the escitalopram overdose. A 15-year-old Caucasian woman was presented with an escalopram overdose after a suicide attempt. The patient has a lengthy QT period of torsade de point incidents. The patient was received and monitored in the telemetry facility. She proceeded to exhibit the persistently extended QT period after the resolution of torsades de punes. She was diagnosed with a congenital QT condition by the cardiology clinic. In this situation, an escitalopram overdose is seen to trigger an immediate QT extension for a patient who has congenital LQTS and the value of an electrocardiogram before SSRIs are started, particularly for those at high risk of QT prolongation.

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The main aim of the study is to assess and evaluate the drug related problems in the pulmonology department. It was a Prospective Interventional study in PULMONOLOGY DEPARTMENT conducted at Manipal Super Speciality Hospitals, Vijayawada, Andhra Pradesh for a period of twelve (12) Months from February 2018 to February 2019. We have collected 115 cases from Pulmonology Department. During the study period, we have collected a total number of 115 cases under the pulmonology department. We found that Males are more effected than Females with percentage of 68% (n=78) and 32% (n=37). In the present study 27 DRP’s were found in which 10 Adverse Drug Reactions, 4 Untreated conditions, 4 Inappropriate drug according to guidelines, 4 inappropriate timing of administration, 2 Drug dose too high, 2 No Drug treatment inspite of existing indication, 1 prescribed drug not available. The result of the present Interventional study shows that Clinical pharmacy services helps in identify and resolve drug related harms in discussion with health care professional. In our study we found 27 DRP’s based on PCNE V8.02 classification in which 22 DRP’s were informed to the physician, and 5 DRP’s were identified by the physician. The study shows that there is a need for Clinical Pharmacist services in healthcare to reduce DRP’s by monitoring patient’s drug therapy by which Pharm. D (Doctor of Pharmacy) can be suggested as Clinical Pharmacist since they are well versed in the subject areas like Clinical pharmacy, Clinical Pharmacology, Clinical Toxicology and Pharmacotherapeutics.

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