Brain abscess is a collection of pus in the parenchyma of brain. Most common infecting organisms are streptococci, staphylococci and anaerobes, depending upon the source from which it originates. Clostridium cadaveris and Clostridium sporogenes are common organisms found in the gastrointestinal tract of humans, rarely producing disease. Few cases of bacteremia and abscesses are reported with these organisms. We hereby report the first case of brain abscess with C cadaveris and C. sporogenes in a young male with good outcome by surgical and medical management. J Microbiol Infect Dis 2019; 9(3):129-132.