Background; SARS-CoV-2, the novel corona virus that originated in Wuhan, China in late December is a positive single stranded RNA virus. COVID-19, a disease caused by the SARS-CoV-2 is characterized by symptoms such as fever, sore throat, dry cough, loss of sense of taste and smell etc. The symptoms may range from asymptomatic, mild, moderate, severe and critical. The virus enters through its spike protein (S) to the ACE2 receptors. The aim of the study is to evaluation of ferritin, D-dimer, CRP and IL-6 in patients who affected with COVID-19. Patients and methods; A cross-sectional conducted in many Hospitals in Baghdad. This study conducted between January to June 2022 on patients infected with the Corona virus.  A total of sixty subjects were participated in the present study. Thirty patients of both sexes, with different ages and in the severity infection with the Corona virus, divided into two groups. Results; There were significant elevations in the concentration of serum ferritin and D dimer of COVID-19 patients, as compared with control healthy subjects. Also, there is significant elevation in the concentration of serum CRP of patients with COVID-19, as compare with control healthy subjects.