Background: Substance abuse is a major challenge in Egypt due to changing pattern of abuse and its threating to health, social and economic build of the community. Aim of the work: the present work aims to demonstrate the pattern of substance abuse in Assiut governorate.Also to study the liver, kidney functions and electrocardiographic changes among addicted patients admitted to Addiction

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Background Tramadol dependence is prevalent across Egypt. The allegation that it can improve sexual function is the main reason for its popularity among young men. This study aims to determine the serum level of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in tramadol abusers. Results Serum testosterone (5.18 ± 1.95) and LH (7.79 ± 1.63) of abusers showed highly significant lower levels than control subjects, while FSH showed no significant difference between abusers and controls. There was no significant difference of hormonal levels in subjects according to the duration of abuse and dose of tramadol. Conclusions The results indicate that tramadol abuse causes a pronounced lowering of testosterone and LH levels that is not correlated to the duration of abuse and dose of tramadol.