‫ــــــ‬ ‫ــــــــــــــــ‬ ‫ـــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ‬The goal of this study To assess if high frequency ultrasound correlates with modified Rodnan skin score and inflammatory markers and if it can differentiate between Systemic sclerosis and healthy individuals and if HFU can detect subclinical skin thickening. We recruited 30 consecutive patients with SSc and 40 controls in this case control study. Skin thickness was