Salinity is one of the main environmental stresses, and it affects potato growth and productivity in arid and semiarid regions by disturbing physiological process, such as the photosynthesis rate, the absorption of essential nutrients and water, plant hormonal functions, and vital metabolic pathways. Few studies are available on the application of combined nanomaterials to mitigate salinity stress on potato plants (Solanum tuberosum L. cv. Diamont). In order to assess the effects of the sole or combined application of silicon (Si) and potassium (K) nanoparticles and biochar (Bc) on the agro-physiological properties and biochemical constituents of potato plants grown in saline soil, two open-field experiments were executed on a randomized complete block design (RCBD), with five replicates. The results show that the biochar application and nanoelements (n-K and n-Si) significantly improved the plant heights, the fresh and dry plant biomasses, the numbers of stems/plant, the leaf relative water content, the leaf chlorophyll content, the photosynthetic rate (Pn), the leaf stomatal conductance (Gc), and the tuber yields, compared to the untreated potato plants (CT). Moreover, the nanoelements and biochar improved the content of the endogenous elements of the plant tissues (N, P, K, Mg, Fe, Mn, and B), the leaf proline, and the leaf gibberellic acid (GA3), in addition to reducing the leaf abscisic acid content (ABA), the activity of catalase (CAT), and the peroxidase (POD) and polyphenol oxidase (PPO) in the leaves of salt-stressed potato plants. The combined treatment achieved maximum plant growth parameters, physiological parameters, and nutrient concentrations, and minimum transpiration rates (Tr), leaf abscisic acid content (ABA), and activities of the leaf antioxidant enzymes (CAT, POD, and PPO). Furthermore, the combined treatment also showed the highest tuber yield and tuber quality, including the contents of carbohydrates, proteins, and the endogenous nutrients of the tuber tissues (N, P, and K), and the lowest starch content. Moreover, Pearson’s correlation showed that the plant growth and the tuber yields of potato plants significantly and positively correlated with the photosynthesis rate, the internal CO2 concentration, the relative water content, the proline, the chlorophyll content, and the GA3, and that they were negatively correlated with the leaf Na content, PPO, CAT, ABA, MDA, and Tr. It might be concluded that nanoelement (n-K and n-Si) and biochar applications are a promising method to enhance the plant growth and crop productivity of potato plants grown under salinity conditions.

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Introduction: The levonorgestrel intrauterine system (LNG-IUS) is a long-acting hormone-releasing uterine device that has many non-contraceptive benefits. The study aims to assess the safety and efficacy of LNG-IUS in the management of adenomyosis. Material and methods:We searched the following bibliographic databases: MEDLINE via PubMed, SCOPUS, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and Google Scholar for the relevant studies which used LNG-IUS in management of patients with clinically or ultrasonographic diagnosed adenomyosis.The main outcome measures are pain score at the end of follow-up, bleeding, symptomatic relief, uterine volume (mL), endometrial thickness (mm) and/or hemoglobin level.Results: Ten prospective studies (patients n = 551) were included. The overall effect estimates showed that the LNG-IUS led to significant reductions in pain score after 12 months (standardized mean difference [SMD[ −3.87, 95% confidence interval [CI] −5.51 to −2.23, P < .001), 24 months (SMD −5.56, 95% CI −9.80 to −1.32, P = .01) and 36 months of insertion (SMD −3.81, 95% CI −4.27 to −3.36, P < .001). Similarly, the Pictorial Blood Assessment Chart (PBAC) showed significant reduction up to 36 months after LNG-IUS insertion (SMD −2.32, 95% CI −2.91 to −1.73, P < .001).The LNG-IUS led to significant reductions in the uterine volume 12 months (SMD −.60, 95% CI −0.88 to −.31, P < .001) and 36 months after insertion (SMD −0.42, 95% CI −0.69 to −0.14, P = .003). Conclusions:LNG-IUS is a promising and effective option for the management of adenomyosis. Its use effectively reduced the severity of symptoms, uterine volume and endometrial thickness, and improved laboratory outcomes. K E Y W O R D Sadenomyosis, hormonal intrauterine device, levonorgestrel intrauterine system, pain relief

It appears that hysteroscopy is a useful tool in the diagnosis and treatment of the causes of recurrent miscarriage that can be performed safely without anesthesia in most cases. The prevalence of uterine anomalies in patients with recurrent miscarriages is 54.5%, septate uterus is the most common anomaly and for this reason uterine anomalies should be systematically assessed in patients with recurrent miscarriage.

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