No abstract

Obesity, a global health concern is associated with the dysbiosis of intestinal microbial composition. This study aims to investigate the potentials of urolithin A (Uro-A), in reducing body weight gain through the modulation of the gut microbiota. Rats were fed on a high-fat diet and administered with Uro-A. Changes in the composition of the gut microbial community were analyzed using 16S rDNA gene sequencing. Our results showed that Uro-A significantly decreased body weight gain and modulated the compositions of gut microbes that are related to body weight, inflammation, impaired glucose, and dysfunctional lipid metabolism, which are all associated with obesity.