Inflammatory properties and adjuvant potential of synthetic glycolipids homologous to mycolate esters of the cell wall of Mycobacterium tuberculosis.Hermann Giresse TIMA (1), Juma'a Raheem AL DULAYYMI (2), Olivier DENIS (1), Pauline LEHEBEL (1), Klarah Sherzad BAOLS (2), Mohsin Omar MOHAMMED (2), Laurent L'HOMME (3), Mohaned Mohammed SAHB (2), Georges POTEMBERG (1), Sylvie LEGRAND (3), Roland LANG (4), Rudi BEYAERT (5), Jacques PIETTE (3), MarkStephen BAIRD (2)#, Kris HUYGEN (1)#, Marta ROMANO (1)*#.

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R- and S-Glycerol mycolates derived from single synthetic α-, keto- and methoxy-mycolic acids are described.

This research includes reaction and condensation between substituted 4-aminopyridine and 4-(N, N-dimethyl amino benzaldehyde) to produce Schiff base derivative (3), the compound (3) was selected to react with a different compound such as Thioglycolic acid, Phthalic anhydride, and maleic anhydride, to produced new ring of Thiazolidine derivatives and oxazepine derivatives structures (4,5,6,7,8,9,10,11,12), respectively. The final compound was characterized the structure by Fourier transform-infrared spectroscopy, H-Nuclear magnetic resonance (H-NMR) in addition to the Carbon, Hydrogen, Nitrogen (CHN) analyzer. Biological activity has been considered for the final structures and achievements of multi drugs.

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