In the present age, the pharmaceutical application continues to increase and this results in the environmental pollution. As a result, pharmaceutical control is a common technique in many labs. This project is on the improvement of the procedure to determine a small amount of ciprofloxacin (CF) in bio-environmental sample. Regarding the fact that each method requires preliminary measures to preconcentrate and prepare analyte prior to measurement and recognition. In recent study, preconcentration of samples containing CF (as antibiotic) based on solid-phase microextraction method using silica-coated magnetic nanoparticles modified with salicylic acid (SA) was proposed which acted as sorbent. In addition, UV-Vis spectrophotometry was carried out to determine the amount of CF. The wavelength of maximum absorption (λmax) for this drug was 275 nm. Also, the optimum conditions of various parameters such as pH of solution, amount of magnetic nanoparticles, time, the effect of stirring speed on the extraction and desorption, the rate of centrifugation, the volume of aqueous and organic-phases, temperature and salt effect were investigated. The dynamic range was obtained between 0.05-0.15 mg L -1 , LOD and RSD (%) were 0.002 mg L -1 and 1.878 respectively. Results showed using this procedure increased the concentration factor to 68.36. Relative recovery was achieved by spike method.

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