The purpose of this research was to identify factors that affect the resistance of the population of eastern DR Congo to be vaccinated against Covid-19. Therefore, quantitative research based on primary data obtained from a survey was conducted in North Kivu Province. The questionnaire had 35 items with 410 respondents. After processing of the data, 318 records were retained. There were 151 women (48.55%) and 160 men (51.45%). Using the exploratory factor analysis (EFA), the authors shifted from 35 items to 6 main factors affecting vaccine resistance when they used Cronbach's Alpha test for each rotated factor. Cronbach's Alpha test for the reliability of the questionnaire was 0.67; the Bartlett test was 2490.79, and the KMO test was 0.70. Total cumulative variance was 30.1% explained by the six retained which are Psycho-medical background, Demographic, Social origin, Lack of trust in government actions, Previous issues about the Ebola vaccine in North Kivu, and Socio-political belonging.