This study investigated the determinants of overweight/obesity in adolescents. A cross-sectional survey was carried out on 1157 adolescents. Weight and height were measured. Information on socio-economic status (SES), dietary intakes, physical activity, and sedentary behaviours were collected by a self-administered questionnaire. Binary and multivariate binary logistic regressions were used to obtain the relationships and odds-ratios, respectively. The prevalence of overweight and obesity was higher among adolescents in low- or high-income families, adolescents whose mothers worked out of home, adolescents whose parents were both overweight, adolescents who watched a lot of TV or had excessive energy intake, adolescents with lower physical activity or lower intake of dietary fibre, those who skipped breakfast ≥ 4 times per week, and those with low and high fat intake. However, multiple logistic regression analysis showed that only energy intake was associated with increased odds and vegetables and fibre intake were associated with a reduction in the odds of being overweight (all p<0.05). Adolescents from middle SES showed a lower risk of overweight/obesity than low and high SES due to better dietary intakes and less sedentary behaviours. Therefore, in overweight/obesity prevention programs, adolescents with determined risk factors from families with low and high SES should receive attention.

Background: Infertility is a significant psychological stressor among infertile couples. Aggressive behaviour such as domestic violence may be the consequence of this situation. Aims: To determine the relationship between domestic violence and infertility and its associated factors. Methods: This unmatched case-control study was conducted on 400 women who were referred to Al-Zahra teaching Hospital in Rasht, Islamic Republic of Iran, from May to December 2015. The data were collected by WHO Domestic violence questionnaire, which was validated in the Islamic Republic of Iran. Data were analyzed by using descriptive and analytical statistic (Chi square, t test, and logistic regression). Results: Out of the 200 infertile women 136 (68%) reported a history of physical violence, 120 (60%) had experienced sexual violence and 140 (70%) had psychological violence. There was a significant relationship between infertility and physical, sexual and psychological violence (P < 0.05). Logistic regression analysis revealed that the education level of women [OR= 0.176, 95% CI (0.070-0.446)], unemployment husband [OR=15.83, 95% CI (1.307-191.977)] and infertility [OR= 0.133, 95% CI (0.057-0.31)] were associated with domestic violence (P < 0.05). Conclusions: In this study there was a relationship between infertility and physical, sexual and psychological violence and infertile women were more likely to encounter domestic violence. Screening for domestic violence is necessary for infertile couples.

Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%. Humans normally have more beige and potentially beige-able fat than brown fat. Strategies to increase beige fat differentiation and activation may be useful for the treatment of obesity and diabetes. Mice were fed chow or high-fat diet (HFD) with or without the iron chelator deferasirox. Animals fed HFD + deferasirox were markedly lighter than their HFD controls with increased energy expenditure (12% increase over 24 h, p < 0.001). Inguinal fat from HFD + deferasirox mice showed increased beige fat quantity with greater Ucp1 and Prdm16 expression. Inguinal adipose tissue explants were studied in a Seahorse bioanalyser and energy expenditure was significantly increased. Deferasirox was also effective in established obesity and in ob/ob mice, indicating that intact leptin signalling is not needed for efficacy. These studies identify iron chelation as a strategy to preferentially activate beige fat. Whether activating brown/beige fat is effective in humans is unproven. However, depleting iron to low-normal levels is a potential therapeutic strategy to improve obesity and related metabolic disorders, and human studies may be warranted.

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