Hepatic peliosis is a rare vascular histological feature characterized by dilatation and rupture of sinusoidal blood-filled spaces within the liver. There may be occur on other organs. it observed in human and occurred in aged rat. there is a complex interplay could share in peliosis formation. loss of HGF/c-met mediate fas apoptosis which may be a part of axis explain peliosis hepatica. additional knockdown of hepatocyte growth factor widening sinusoidal space and enhanced hepatocyte dissociation. notably, Egfr and tnfr1 also mediate fas apoptosis and could e apart of key mechanism of peliosis. also peliosis seen in transgenic model like Hgf transgenic model treated with diethyl nitrosamine and c-myc hepatocellular carcinoma of c-myc transgenic model of liver cancer. while vegf have dual role in protection or induction of liver peliosis. taken all, many factors could play a role in induction of liver peliosis.