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INTRODUCTION:The use of platelet concentrates remains controversial. Several techniques for platelet concentrates are available and each method leads to a different product with different biology and potential uses. Platelet rich fibrin (PRF) is an autologous biomaterial composed of a fibrin clot matrix entrapping leukocytes, cytokines, living progenitor cells, and platelets capable of releasing various growth factors. One of the recent platelet concentrates is the mineralized plasmatic matrix (MPM) which has a different way of preparation. It creates a stable homogeneous single-moldable compound. OBJECTIVES: The aim of this experimental study was to compare the effect of PRF to MPM when combined with biphasic calcium phosphate alloplast in treating horizontal critical sized ridge defects in a canine model. MATERIALS AND METHODS: A split mouth design was carried out using the third and fourth mandibular premolars of two healthy mongrel dogs. A total of eight horizontal critical sized ridge defects were surgically created. The defects on the left side (group I); were managed with MPM composite, MPM compact layer, then collagen membrane. On the right side (group II); defects were managed with PRF mixed with biphasic calcium phosphate alloplast followed by the application of PRF compact strips, then collagen membrane. The dogs were sacrificed after 4 weeks. Samples were dissected and prepared for histological evaluation. RESULTS: Histological results showed that quality of bone formed in MPM group was superior to PRF. This was evident with the formation of well-organized compact bone in MPM specimens versus immature woven trabecular bone in PRF ones. CONCLUSIONS:The fibrin network that is produced in the MPM composite allows for its homogeneity. This offers a very good stability for the graft which was found to be more effective in enhancing wound healing during guided bone regeneration of horizontal ridge defects.

INTRODUCTION: Treatment of molar furcation defects remains a considerable challenge in clinical practice. Furcation defects treatment can vary according to the type and location of the defects. Regenerative procedures are one of the treatment modalities in furcation involvement. In this study Amnion Chorion membrane(ACM) was used with an alloplast to manage grade II furcation defects. OBJECTIVES The aim of this study was to evaluate clinically and radiographically the effect of ACM augmented with alloplast bone graft in management of grade II furcation involvement. MATERIALS AND METHODS: This study was conducted clinically on fourteen patients with fourteen grade II furcation defects. Patients were divided into two groups: test group: included seven furcation defects that were treated by alloplast bone graft covered by ACM, and control group: including seven furcation defects treated with alloplast bone graft covered by a resorbable collagen membrane. Probing depth (P D), clinical attachment loss(CAL)were measured at baseline,3, and 6 months. Cone beam computed tomography(CBCT)was performed at baseline,6, and9months to evaluate bonefill in the furcation defect. RESULTS: ACM has shown reduction in probing depth and clinical attachment loss, and enhanced bone formation when compared to control group treated with resorbable collagen membrane. CONCLUSIONS: ACM is an effective, easy to handle, safe, and time saving membrane that can be used in periodontal regeneration.

INTRODUCTION: Lepidium sativum, commonly known as garden cress is a herb that is native to Egypt and West Asia. Its seeds are rich source of proteins, dietary fiber, omega-3 fatty acids, iron, other essential nutrients and phytochemicals. Garden cress is widely used in folk medicine for the treatment of many diseases. Periodontitis is defined as an inflammatory bacterial-induced disease that damages the soft tissue and gradually destroys the periodontal ligaments and supporting alveolar bone. Periodontitis can cause teeth to loosen or lead to tooth loss. Different methods, such as biomechanical measurements, surgical approaches are used to treat periodontitis. OBJECTIVE: to evaluate histologically and ultra-structurally the possible effect of garden cress therapy on alveolar bone healing in rats with ligature induced periodontitis. MATERIALS AND METHODS: Forty-five adult male Sprague-Dawley rats of 6 months old (200-250 grams in weight) was used in this study. They were divided into 3 equal groups: group A; (control group), group B; (ligature induced periodontitis) and group C :(ligature induced periodontitis with garden cress administration). Ligature was removed after 11 days. Garden cress was applied after ligature removal systemically by using oral gavage. Rats were sacrificed after six weeks from the ligature removal. Mandibles were dissected out and were prepared for histological and scanning electron microscopic evaluation. RESULTS: After 6 weeks the specimens of group B (periodontitis group) showed alveolar bone loss, while in group C (garden cress group) showed relative restoration of alveolar bone. Results of scanning electron microscope revealed an irregular & porous bone surface of group B, while Group C showed relative smooth and regular alveolar bone. CONCLUSION: Garden Cress systemic administration accelerates alveolar bone healing and enhances bone formation in periodontal diseases.

Introduction: Treatment of furcation defects especially critical size defects remains a considerable challenge in clinical practice. Treatment modalities vary according to the type and location of the defects. Regenerative procedures are one of the treatment modalities in furcation involvement. Objectives:The aim of this study was to evaluate histomorphometrically the regenerative potential of amnion chorion membrane (ACM) on the management of induced grade II furcation defects and compare it to collagen membrane. Material and methods:This study was conducted on eight adult male Mongrel dogs, about 18-24 months old, weighing approximately 18-24 Kgs. On the left sides; the created defects were filled with β-tricalcium phosphate + hydroxy apatite and covered by amnion chorion membrane (study group). While on the right sides; the created defects were filled with the β-tricalcium phosphate + 2 Alexandria Dental Journal. Volume XX Issue X.hydroxyapatite then covered by collagen membranes (control group).Results: ACM has shown superior results in bone formation when compared to control group treated with resorbable collagen membrane. Conclusion:ACM is an effective, easy to handle, safe, and time saving membrane that can be used in periodontal regeneration and management of grade II furcation defects.