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: COVID-19 is a respiratory disease caused by a newly identified coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since its inception in late December 2019, COVID-19 has led to a remarkable loss of human life all over the world. To overcome the unprecedented challenges posed by COVID-19 pandemic to the public and economic health, strengthening of the healthcare system is utmost needed. In this regard, research communities are putting efforts in developing an advanced healthcare system, that could reduce the severe impacts of this pandemic. Nanotechnology is such an advanced technology which has contributed significantly in producing powerful arsenals for the frontline warriors, in this battle against COVID-19. It has offer opportunities for development of fast and accurate point-of-care testing, efficient therapeutics and vaccines, potent sanitizers, facemasks, personal protective equipment etc. against SARS-CoV-2. However, associated toxicity, long procedures of clinical trials, uncertain health risks etc. are some points which are still debatable. The present paper provides an overview of COVID-19 specific therapeutics and vaccines with an emphasis on nano-based strategies, which are significantly contributing towards the success of mitigation measures and strategies against COVID-19. Furthermore, the associated challenges, current limitations, and opportunities in this field are discussed.

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