SUMMARYThis paper provides a first insight on tube configurations based on the hexagonal shape (hexagrid) for tall buildings. The idea is to investigate the mechanical properties of hexagrid to assess their applicability in tall buildings and to compare their potential efficiency to the more popular diagrid systems.For the above purposes, a general homogenization approach has been established for dealing with any structural patterns, and a methodology for characterizing the structural patterns from the mechanical point of view has been developed and specified for hexagrids and diagrids. Then on the basis of a simple stiffness criterion, a design procedure has been proposed and applied to a tall building case study, and several structural solutions (both hexagrids and diagrids) have been designed and assessed by varying the major geometrical parameters of the patterns.