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New demands on modern manufacturing systems have emphasised the need for higher levels of overall system reliability. The main focus of this paper is that of the reliability of manufacturing personnel and the way in which this interrelates with overall system performance. A framework - Human Error and Disturbance Occurrence in Manufacturing Systems (HEDOMS) is proposed, which integrates human reliability with overall system performance, relating human error with disturbance occurrence and handling. The HEDOMS framework has been extended into a toolkit to enable the identification of potential for human error and disturbance occurrence in manufacturing systems, as well as the definition of suitable error reduction measures.