Increased thickness of the outer plexiform layer (OPL) of the fovea in central serous chorioretinopathy (CSC) has been previously reported. However, to our knowledge only one paper has given a concrete value of the thickness of the outer plexiform layer (OPL) of the macula in a patient with unilateral CSC. Here we report the outer plexiform and outer nuclear layer (ONL) thickness as measured with spectral domain optical coherence tomography (SD-OCT) in a patient with acute central serous chorioretinopathy in the left eye, and in a second patient with recurrent central serous chorioretinopathy in both eyes. Both patients received oral eplerenone treatment.