The design of a new type of amperometric enzyme electrode, exploiting ferrocene as mediator between enzyme and electrode, is described. Its use is illustrated by application to the determination of glucose through the use of glucose oxidase. Other flavoproteins accept ferrocene as a mediator, as do peroxidases. The synthesis of ferrocene analogues of drugs, e.g. lidocaine and theophylline, permits the development of analytical methods employing components of the immune system.

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