ObjectivesErythrocyte sedimentation rate (ESR) and serum level of C-reactive protein (CRP) are the acute phase reactants most commonly determined in patients with rheumatic diseases. The indices are affected by different factors, but both of them are applied for evaluation of the disease activity in patients with inflammatory disorders of the musculoskeletal system.Material and methodsThe authors compared the results of ESR and CRP, which were carried out during routine diagnosis in 200 patients admitted to the Department of Rheumatology.ResultsA significant correlation between ESR and CRP was found (ESR after 1 h/CRP: correlation coefficient 0.6944, ESR after 2 h/CRP: correlation coefficient 0.6126). There was no difference in ESR or CRP between male and female patients, and patients older than 40 years had higher ESR and CRP.ConclusionsThe obtained results support the usefulness of both indices in the clinical practice of rheumatologists.

Tubular polymeric structures have been recognized in the treatment of peripheral nerves as comparable to autologous grafting. The best therapeutic outcomes are obtained with conduits releasing therapeutic molecules. In this study, a new approach for the incorporation of biologically active agent-loaded microspheres into the structure of chitosan/polycaprolactone conduits was developed. The support of a polycaprolactone helix formed by 3D melt extrusion was coated with dopamine in order to adsorb nerve growth factor-loaded microspheres. The complex analysis of the influence of process factors on the coverage efficiency of polycaprolactone helix by nerve grow factor-loaded microspheres was analyzed. Thus, the PCL helix characterized with the highest adsorption of microspheres was subjected to nerve growth factor release studies, and finally incorporated into chitosan hydrogel deposit through the process of electrophoretic deposition. It was demonstrated by chemical and physical tests that the chitosan/polycaprolactone conduit meets the requirements imposed on peripheral nerve implants, particularly mimicking mechanical properties of surrounding soft tissue. Moreover, the conduit may support regrowing nerves for a prolonged period, as its structure and integrity persist upon incubation in lysozyme-contained PBS solution up to 28 days at body temperature. In vitro cytocompatibility toward mHippoE-18 embryonic hippocampal cells of the chitosan/polycaprolactone conduit was proven. Most importantly, the developed conduits stimulate axonal growth and support monocyte activation, the latter is advantageous especially at early stages of nerve regeneration. It was demonstrated that, through the described approach for controlling spatiotemporal release of nerve growth factors, these biocompatible structures adjusted to the specific peripheral nerve injury case can be manufactured.

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Zmiany w raportowaniu biznesowym na przestrzeni ostatnich lat WstępW dzisiejszych czasach rośnie stopień skomplikowania sprawozdań finansowych, co powoduje problemy nie tylko ze znalezieniem właściwych informacji, ale również z ich zrozumieniem nawet przez wykwalifikowane osoby. Zdarza się także, że wiele z raportów nie zawiera informacji niefinansowych, co wpływa na tworzenie wartości podmiotu w długim i krótkim okresie. Raportowanie biznesowe oznacza przede wszystkim przekazywanie interesariuszom informacji finansowych i niefinansowych w postaci sprawozdań finansowych oraz innych raportów zewnętrznych takich jak: raporty z działalności zarządu, społeczne, środowiskowe, społecznej odpowiedzialności, zrównoważonego rozwoju, o kapitale intelektualnym 1 .