Polymer grafted magnetic graphene oxide (GO–PVP–Fe3O4) as an efficient nanocarrier for the delivery of anticancer drug quercetin.

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Co-delivery of chemotherapeutic drugs with protein (avidin) within a solitary nanocarrier system has emerged as a promising combination therapy approach for treating cancers owing to their synergistic effect. In this study, we developed a potential nanocarrier by using graphene oxide (GO), activated folic acid (FA), polyethylene glycol (PEG), and TiO 2 nanoparticles. PEG was introduced to enhance the nanocarrier's water solubility and biocompatibility. Further the synthesized primary nanocarrier that is, GO-FA-PEG-TiO 2 employed with avidin-biotin (Avi/Bio) system and synthesized more efficient nanocarrier that is, GO-FA-PEG-TiO 2 -Avi/Bio to enhance potential anti-tumor activity and targeted co-delivery of anticancer drug, SN-38. The morphological analysis of nanocarrier GO-FA-PEG-TiO 2 -Avi/Bio was confirmed by basic characterization techniques including RAMAN, Fourier transforms infrared, Thermo gravimetric Analyzer, and Field Emission Scanning Electron Microscopy. The loading capacity of SN-38 revealed that the nanocarrier integrated with Avi/Bio complex possessed higher adsorption capability than nanocarrier without Avi/Bio system. Furthermore, GO-FA-PEG-TiO 2 -Avi/Bio showed pH-responsive behavior of releasing SN-38. In-vitro experiments confirmed sustained release of the drug, with a better performance at physiological pH (7.4) than at acidic pH (5.0). The developed nanocarrier with Avi/Bio complex showed higher cytotoxic effects than the GO-FA-PEG-TiO 2 system. The cytotoxicity screening of GO-FA-PEG-TiO 2 -SN-38 and GO-FA-PEG-TiO 2 -Avi/Bio-SN-38 was conducted with MDA-MB-231 cells. Thus, GO-FA-PEG-TiO 2 -Avi/Bio system, when used as nanocarriers, showed high payload capacity to target cancer cells with increased cytotoxicity.

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