Chemotherapy has been used for treating chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with incosistent results. Chemotheraphy has been used for treating with inconsistent results. Rituximab is a chimeric monoclonal antibody directed against the CD20 antigen, used to treat B‐cell lymphoma and reported to be effective in some neuropathies with IgM autoreactivity. We saw a 72‐year‐old man with CIDP refractory to steroids, plasma exchange, IV Ig, and cyclosporin. He was unable to walk; severe impairment was present also at the upper limbs. Electrodiagnostic studies revealed slowing of motor and sensory conduction velocities, and prolonged distal motor latencies. Immunoelectrophoresis evidence an IgM/k monoclonal gammopathy. Antibodies to Myelin Associated Glycoprotein (MAG) and other peripheral nerve antigens were negative. Bone marrow biopsy documented a small lymphocytic B‐cell lymphoma (CD20+). Treated with Rituximab (375 mg/m2 for 4 weeks), the patient presented at follow‐up evaluations (3, 6 and 8 months later) a progressive improvement. Eventually, he was able to walk, and regained full strength at upper limbs. Consistently, electrophysiological studies improved. We suggest considering treatment with Rituximab in CIDP resistant to conventional therapy, at least in cases associated with IgM lymphoproliferative diseases.

The present study was carried out to investigate the antihyperglycemic activity of the leaves of Toona ciliata hydroalcoholic extract in streptozotocin-induced diabetic rats. In the present study, effect of oral administration of T. ciliata leaves extract (0.2, 0.4g/kg body wt.) for 15 days on the level of blood glucose, serum cholesterol, triglycerides, urea, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) in normal and streptozotocininduced diabetic rats were evaluated. Histology of liver, kidney and pancreas were also studied. A significant decrease in blood glucose, serum cholesterol and triglycerides levels while total protein and HDL-C level was found to be increased as compared with the diabetic control group. The histology study of the diabetic rats treated with T. ciliata extract showed the significant results by showing recovery almost near to normal rats. The extract of the plant leaves at both the doses (0.2, 0.4g/kg body wt.) showed prominent effect and the finding suggest that Toona ciliata has significant antihyperglycemic activity in streptozotocin induced diabetes in rats.

No abstract

No abstract

No abstract