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: To overcome ever increasing cases of antifungal resistance and circumventing side effects and drug interactions related with currently available drugs has impelled the need to expedite the process of drug discovery and development of novel antifungals. 1,4-Disubstituted 1,2,3-triazole has gained tremendous interest in last two decades mainly because of its ease of synthesis via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and its broad spectrum of chemotherapeutic potential. 1,2,3-Triazole is an excellent pharmacophore which has been used as a bioisostere for obtaining libraries of new medicinally important scaffolds. The present review focus on the recent advances (2016-2021) of 1,2,3-triazole derivatives obtained by CuAAC as potential antifungal agents that may facilitate triazole based antifungal development process.

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Nine new substituted aryloxy-4-thiazolidones have been prepared from corresponding schiff bases and thioglycolic acid in benzene using Stark and Dien apparatus. The synthesized compounds were identified by spectral studies and screened for antimicrobial activity.