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Introduction: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes and even from sites, which normally do not contain lymphoid tissue. The incidence of extra nodal non Hodgkin lymphoma (ENL) is rising throughout the world. However, data regarding ENL as a group is limited. This study was undertaken to ascertain the prevalence, anatomical distribution, and histological subtypes of extranodal non-Hodgkin lymphoma (NHL) from a tertiary care institute in Rajasthan. Materials and Methods: This was a cross-sectional study conducted in the Department of Pathology over a period of 2-years. Detailed clinical history, routine complete blood count, microbiological status was obtained from the medical records. Hematoxylin and eosin slides were reviewed and immunohistochemistry was performed using a panel of antibodies depending on the morphology. All cases were classified based upon morphologic and immunophenotypic criteria according to World Health Organization 2008 classification. Results: Primary extranodal NHL constituting 54.7% (70/128) of all NHL and the majority of patients were from higher age group with peak incidence seen in fifth and sixth decade of life. In the pediatric population, the most common site was GI tract (45.5%) followed by skin (18.2) and the most common morphology was diffuse large B-cell lymphoma (54.5%).

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