Chronic Arsenic Toxicity may have varied clinical presentations ranging from non-cancerous manifestations to malignancy of skin and different internal organs. Chronic arsenic exposure results in dermatologic manifestations prior to overt clinical neuropathy. Arsenic neuropathy causes painful paresthesias and, with higher level or continued exposure, length-dependent weakness. We are reporting two cases of chronic arsenic poisoning who presented initially as peripheral sensory motor neuropathy and skin manifestations. Arsenic poisoning was suspected because many of the other family members also developed similar symptoms simultaneously. The hair samples of these patients contained markedly elevated levels of arsenic. Also the water samples from their household and the neighboring households were found to have alarming levels of inorganic arsenic. Provision of arsenic free drinking water halt further deterioration of symptoms and there was significant improvement of their dermatological & neurological conditions. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17184 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 128-131

Background and objectives: Migraine is now ranked as number 19 among all diseases causing disability by WHO1 which is characterized by recurrent attacks of various combinations of headache and neurological, gastrointestinal and autonomic symptoms2 accompanied by photophobia, phonophobia and vomiting3. The treatment of migraine involves acute, preventive drugs and non-pharmacological strategies. The basic principle in management of migraine is avoiding the trigger factors, blocking the mediators and splinting the end organ4. Though there is no significant curable treatment but there are some internationally proven and well accepted prophylactic medication which reduces headache severity, frequency, duration and risk for rebound5. Sodium valproate and pizotifen are commonest of them6, where sodium valproate is more effective than pizotifen in the prophylaxis of migraine patients. Methods: This study was a single blind randomized clinical trial carried out in the neurology outpatient department of Bangabandhu Sheikh Mujib Medical University, Dhaka (BSMMU) for the period of 2 years, among adult patients between the age of 16-50 years. Results: A total of 120 patients were included & divided into two groups such as group-A(60 patients) treated by sodium valproate & group-B(60 patients) treated by pizotifen for a period of 6 months and followed up every two months for 3 times and showed sodium valproate is more effective than pizotifen. Conclusion: This study permit to conclude that efficacy of sodium valproate is more than pizotifen in the prophylaxis of migraine patients. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17174 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 81-87

IntroductionNow-a-days Carpal tunnel syndrome (CTS) is an emerging health problem in Bangladesh especially among middle and old age female population. It is the compression of the median nerve at the wrist (carpal tunnel) in absence of an obvious injury, trauma or surgery which causes significant morbidity and reduces work output in affected patients. Many patients have to change jobs or modify activities to decrease their symptoms 1,2 . Women are three times more likely to develop CTS than men. The prevalence of CTS in general Western European population has been estimated to be at 3% to 5.8% for women and 0.6% to 2.1% for men 3,4 . There are many therapeutic approaches for CTS; among them some are conservative, including avoiding excess use of hand, use of splint, oral steroid, local steroid, diuretics, oral pyridoxine therapy UST etc. Regarding non-conservative measures, surgery is the approach of choice.Patients with CTS should avoid repetitive wrist and hand motions and if possible, should not use Efficacy of Local Corticosteroid in Idiopathic Carpal

Background: The diagnosis of ischemic stroke remains a clinical one, with confirmatory evidence obtained through neuroimaging. ECG changes are common in patients with ischemic stroke. Objective: The objective of this study was to see ECG findings among ischemic stroke patients. Materials and Methods: This study was carried out in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from July 2006 to October 2008. A total of 36 patients with acute Ischemic stroke were selected by purposive sampling method and diagnosed by history, clinical findings ard was confirmed by CT scan of head. The clinical details, investigations of the respondents were reviewed. Data were recorded in a pre-designed data collection sheet. Result: Majority of the subjects were in 7th decade 12(33.3%) and 6th decade 9(25%) with the male to female ratio was 1.25:1. Among the patients with abnormal electrocardiographic findings, 7(19.4%) patients each had myocardial ischemia, 4(11.1%) had conduction block and ventricular arrhythmias, 7(19.4%) had atrial fibrillation, 5(13.9%) had ventricular hypertrophy, 7(19.4%) had myocardial infarction, 6(16.7%) patients had non-specific ST changes. Conclusion: Myocardial ischemia, atrial fibrillation and myocardial infarction are common electrocardiographic findings of ischemic stroke patients. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 23-26

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