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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

SummaryThe effect of tetracycline in the treatment of “Q” fever was investigated in 56 cases, by a technique of sequential analysis.Tetracycline reduced the duration of fever after commencement of treatment by approximately 50%. However, treatment must be commenced within the first three days of illness for this to be of importance.The severity of liver involvement, as estimated by “Bromsulphalein” retention, was significantly less in the treated group.The incidence of phase 1 complement‐fixing antibody six months or more after the onset was significantly less in the treated group.Treatment, essentially blind therapy, is probably justified only for patients who are severely ill, who are at risk of endocarditis because of previous cardiac disease, or who are in the older age groups.

In order to study the kinetics of norethindrone in women, we have administered single doses of 4 preparations of norethindrone (N) to Liverpool, England Department of Pharmacology and Therapeutics, University of LiverpoolNorethindrone ( 17a -ethinyl-I7 (3 -hydroxyestr-4-en-3-one) is a synthetic progestogen which is widely used both on its own and as a component of many combined contraceptive steroid preparations. Despite its widespread use, little is known of the relationship of blood concentrations of norethindrone to efficacy or toxicity. The plasma half-life (tV2) of norethindrone has been variously estimated as between 3 and 5 hrll and about 6 hr 9 , or as a biexponential decay with a terminal tV2 ranging between 3 and 12 hr. 6 We have developed a sensitive radioimmunoassay method for the measurement of norethindrone concentrations in plasma. 2During our initial studies in women taking the combined form of oral contraceptive, we found