Background: Economic consequence analysis is vital for recognizing pipeline comprehensive risk analysis and emergency response planning. Objectives: The purpose of this study was to estimate economic loss due to fire and explosion in petrochemical feed and product pipelines. Materials and Methods:The present study which performed on 47 pipelines of a petrochemical special zone, pertinent pipeline selected by chemical energy potential, flow rate and capital density. Pipeline hazard factor and material factor were determined, and fire and explosion index (F&EI) was calculated. After determination of F&EI, the area of exposure and replacement value in exposure area was determined. Finally, actual maximum probable property damage and business interruption were computed. Results: In the fire and explosion, radius of exposure in adjacent of pipeline was 41.5 meter, and damage factor was 0.87. On the other hand, actual maximum probable property damage was $ M 3.9, and business interruption was $ M 767. Conclusions: Since, Butadiene pipeline has the highest grade of risk in which the degree of fire and explosion is severe, appropriate control actions are required to reduce the risks. Therefore, considering the economic costs and consequences, a comprehensive risk analysis and emergency response planning is highly important for the Petrochemical feed pipelines.