Single isomers of the furanylidene system 8 were synthesized in four steps. The synthesis begins with the dianion of β -keto carbonyls and culminates in a mild, tandem desilylationcyclization reaction using tosylic acid. Compounds synthesized in this study have the potential for further diversifi cation at the alkyne, carbonyl and enol-ether moieties. Hence, the furanylidenes from this study are prospective building blocks for biologically active, furan-containing natural products and their analogs.