Pt(ii) complexes supported by chelating, multidentate ligands containing phenanthridine heterocycles are reported and shown to exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.

Resistance to the platinum-based chemotherapy drug, cisplatin, is significant setback in ovarian cancer. We engineered fatty acid-like Pt(IV) prodrugs that harness the fatty acid transporter CD36 to facilitate their entry...

We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.